| abstract |
The compounds of Figure 1 described are NMDA antagonists. NMDA antagonists are compounds that block the NMDA receptor by interacting with either the glutamate binding site or other sites on the receptor molecule. The compound described is useful in the treatment of tinnitus. Wherein: a) R2 and R5 are taken separately and R1, R2, R3 and R4 are each independently hydrogen, C1-6alkyl, halo, CF3, OH or -OR7 and R5 is methyl or ethyl; or b) R2 and R5 are taken together and are -O-CH2-, forming a chroman-4-ol ring, and R1, R3 and R4 are each independently hydrogen, C1-6alkyl, halo, CF3, OH or -OR7; R6 is described in Figure 2; R7 is methyl, ethyl, isopropyl or n-propyl; R8 is phenyl optionally substituted with up to three substituents independently selected from the group consisting of C1-6alkyl, halo or CF3; X is O, S and (CH2)n; and n is 0, 1, 2 or 3. |