| abstract |
Compounds of formula I wherein, R1 and R2 are independently hydrogen, halogen, trifluoromethyl, C1-6 -alkyl or C1-6 -alkoxy; Y is >N-CH2-, >CH-CH2- or >C=CH- wherein only the bolded atom participates in the ring system; X is -O-, -S-, -CR7R8-, -CH2CH2-, -CH=CH-CH2-, -CH2-CH=CH, -CH2CH2CH2-, -CH=CH-, NR9-(C=O)-, -O-CH2-, -(C=O)- or -(S=O)- wherein R7, R8 and R9 are independently hydrogen or C1-6-alkyl; r is 1, 2, or 3; m is 1 or 2; n is 1 when m is 1 and n is 0 when m is 2; R4 and R5 are hydrogen when m is 1; R4 and R5 are hydrogen or form a bond when m is 2; and R6 is OH or C1-8 -alkoxy; or a pharmaceutically acceptable salt thereof, with the proviso that the compounds 10-(3-(3-carbomethoxy-1-piperidyl)propyl)phenothiazine and 10-(3-(3-carbohexoxy-1-piperidyl)propyl)phenthiazine are not included. These compounds are useful in treating neurogenci inflammation, diabetic neuropathy and rheumatoid arthritis. |