http://rdf.ncbi.nlm.nih.gov/pubchem/patent/NO-995065-L
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c2b9dc89cc4ba060cc73bbf0c90bbb78 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D233-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D231-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D249-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-506 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-501 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D521-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-497 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-496 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4545 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-12 |
| filingDate | 1999-10-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_eba079f32bcbec4cc344ea121dc53381 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_123b8ffcaf5460cda2002f105db51a95 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_123e73e40f33cd0f4b9dbb3faea3fa9d |
| publicationDate | 1999-10-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | NO-995065-L |
| titleOfInvention | Indole derivatives with combined 5HT1A, 5HT1B and 5HT1D receptor antagonist activity |
| abstract | Compounds of formula (I), processes for their preparation and use of them as CNS agents are described: wherein Ra is a group of formula (i) wherein P1 is phenyl, bicyclic aryl, a 5- to 7-membered heterocyclic ring containing 1 to 3 heteroatoms selected from oxygen, nitrogen and sulfur or a bicyclic heterocyclic ring containing 1 to 3 heteroatoms selected from oxygen, nitrogen and sulfur; R 1 is hydrogen, halogen, C 1-6 alkyl. C 1-6 cycloalkyl, CO C 1-6 alkyl, C 1-6 alkoxy, hydroxy, hydroxyC 1-6 alkyl, hydroxyC 1-6 alkoxy, C 1-6 alkoxyC 1-6 alkoxy, C 1-6 alkanoyl, nitro, trifluoromethyl, cyano, SR9, SOR9, SO2R9. SO2NR10R11, CO2R10, CONR1 ° R11, CO2NR10R11, (CH2) cNR10R11. (CH2) CCONR1 ° R11, 6alkyl, CO2 (CH2) COR10, NR10R11, NR1 ° CO2R11, NR10CONR10R11, CR1 ° = NOR11, NR10COOR11, CNR1 ° = NOR11. wherein R 10 and R 11 are independently hydrogen or C 1-6 alkyl and c is 1 to 4 R2 is hydrogen, halogen, C 1-6 alkyl, C 6 -cycloalkyl, C 6 , cyano, CO2R10PCONR1 OR! 1, NR1 ° R11 wherein R10 and R11 are as defined for R1; aerl, 2 or 3; or Ra is a group of formula (ii) (ii) wherein P2 and P3 are independently phenyl, bicyclic aryl, a 5- to 7-membered heterocyclic ring containing 1 to 3 heteroatoms selected from oxygen, nitrogen and sulfur or a bicyclic heterocyclic group containing 1 to 3 heteroatoms selected from oxygen, nitrogen or sulfur; A is a bond or oxygen, S (O) m where m is 0 to 2, carbonyl, CH 2 or NR 4 where R 4 is hydrogen or C 1-6 alkyl; R 1 is as defined above for formula (I) or R 1 is an optionally substituted 5- to 7-membered heterocyclic ring containing 1 to 3 heteroatoms selected from oxygen, nitrogen or sulfur; R 2 and R 3 are independently hydrogen, halogen, C alkyl, C 6 cycloalkyl, C 3-6 cycloalkenyl, C 1-4 alkoxy, acyl, aryl, acyloxy, hydroxy, nitro, trifluoromethyl, cyano, CO2R10, CONR10R11, NR10R11 where R10 and R11 are as defined for R1 and a and b are independently 1 or 3; Y is - NH -, NR $ where R 5 is C 1-6 alkyl or Y is - CH 2 - or - O -; V is oxygen or sulfur; D is nitrogen, carbon or a CH group; Wer (CR16R17) t where t is 2, 3 or 4 and R16 and R17 are independently hydrogen or C1-4 alkyl or Wer (CR16R17) UJ where u is O, 1, 2 or 3 and J is oxygen, sulfur, CR16 = CR17, CR16 = N, = CR16Q, = CR16S or = CR16-NR17; X is nitrogen or carbon; Rb is hydrogen, halogen, hydroxy, C1-6 alkyl, trifluoromethyl, C1-6 alkoxy, C2-salkenyl, C1- cycloalkyl optionally substituted with C1-6 alkyl or aryl; Rc is hydrogen or C1-6 alkyl; and ¿is a single bond when X is nitrogen or a single or double bond when X is carbon. |
| priorityDate | 1997-04-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 60.