| abstract |
The present invention provides new methods for the asymmetric synthesis of (S) -6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1-benzoxazin-2-one of formula (II-1) ) which is useful as a human immunodeficiency virus (HIV) reverse transcriptase inhibitor. In one embodiment, the present invention provides a process for the preparation of an amino alcohol compound of formula (Vi) which comprises adding a toluene solution of 2,3-dichloro-5,6-dicyano-1,4-benzoquinone to a toluene solution of a compound of formula (IH-i), via a compound of formula (IV-i). |