| abstract |
3-piperidyl-4-oxoquinazoline derivatives represented by formula d): wherein R represents an amino group or a cyclic amino group, such as dibenzoazepine, each of which is substituted by a substituted or unsubstituted aryl group, heteroaryl group or the like; n is an integer from 1 to 4; R 3 and R 4 independently represent a hydrogen atom, a lower alkyl group or the like or a pharmaceutically acceptable salt thereof. Compounds (I) have excellent WfP inhibitory activity. These compounds not only inhibit the formation of LDL which is a cause of arteriosclerotic diseases, but also regulate TG, cholesterol and lipoproteins, like LDL in the blood, and regulate lipids in the cells through regulation of MTP activity. The compounds can also be used as preventative or therapeutic agents for hyperlipemia or arteriosclerotic diseases. In addition, it can be used as therapeutic or preventative agents for pancreatitis, obesity, hypercholesterolemia and hypertriglyceride. |