| abstract |
Cephem derivatives of the general formula V /? CH2-S-Q COOR1 wherein Q is an optionally substituted pyridinium group connected to the sulfur atom via a ring carbon atom; X is halogen; Y is hydrogen or halogen; L1 is a furan group, a thiophene group, a C2-C10 alkyl group, or a C2-C10 alkyl group interrupted by one or more groups independently selected from vinyl, S, SO, SO2, SO2 NH, H or xNxri / H on is O or 1; A is CO 2 H, PO 3 H 2, SO 3 H or tetrazole; and R 1 is hydrogen or a carboxyl protecting group; and pharmaceutically acceptable salts and / or prodrugs thereof. The derivatives are gram-positive antibacterial agents particularly suitable for the treatment of diseases caused by methicillin-resistant Staphylococcus aureus (MRSA). |