| abstract |
An inflammatory cytokine production inhibitor containing a polyprenyl derivative represented by general formula I as active ingredient wherein R 1 and R 2 may be the same or different from each other and each represents hydrogen, C 1 -C 2 alkyl, C 2 -C 12 aliphatic acyl , C, - C ,, aromatic acyl or C 8 -C 12 aryl.Uphatic acyl; and n denotes 0 to 2. The derivative has an excellent effect in inhibiting inflammatory cytokine production and an excellent effect for healing inflammatory intestinal diseases such as ulcerative colitis and Crohn's disease, and Behcet's disease, so that it is applicable. as an inflammatory cytokine production inhibitor and a curative or preventive agent for inflammatory intestinal diseases and Behcet's disease. |