| abstract |
There are disclosed ortho-amino substituted benzoylguanides of formula I wherein R (DR (2) NH 2 R (5) NH 2 stands for NR (50) R (6), R (3). R (4) and R (5) are independently R (10) -SOa-, R (11) R (12) N-CO-, R (13) -CO- or R (14) R (15) N-SO2-; or R ( 2) R (3), R (4) and R (5) are independently of SR (21), OR (22), -NR (23) R (24) or -CR (25) R (26) ) R (27) or R (2), R (3), R (4) and R (5) are independently hydrogen, F, Cl, Br. I, CN, -Ua) dg-CdaH2da + 1. - (Xb) dh- (CH2) db-CdeF2de + i, (C3-C8) -alkenyl or -CdfH2dfR (30); or R (2). R (3), R (4) and R (5) independently represent \ R (40) R (41) or - (Xe) - (CH2) ebR (45): where R (3) and R ( 4) however, may not be hydrogen, as well as their pharmaceutically acceptable salts. A process for the preparation of the compounds is also described. The compounds I are made suitable for the treatment of diseases of the cardiovascular system. |