| abstract |
The present invention relates to certain substituted 17/3-substituted carbonyl-6-azaandrost-4-ene-3-ones of formula (I) R1 R5 wherein R1 and R2 are independently hydrogen or lower alkyl and the bond between the carbon atoms bearing R1 and R 2 is a single or double bond, or ii) together is a -CH 2 group forming a cyclopropane ring and the bond between the carbon atoms bearing R 1 and R 2 is a single bond; Preferably, R 3 is hydrogen, halogen or lower alkyl, R * is preferably hydrogen or lower alkyl, X is preferably CH 2, Y is preferably hydrogen, and Z is preferably CONRUR15, and Ru and R15 are a variety of organic groups, and pharmaceutically acceptable salts thereof. , manufacture thereof, medical application and pharmaceutical preparations. |