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filingDate 1993-12-08-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ea5fa1a5bce80ea533fd71af3a413545
publicationDate 1994-06-10-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber NO-934477-L
titleOfInvention PEG hydrazone and PEG oxime-binding reagents and protein derivatives thereof
abstract Methods and compounds for modifying polypeptides with PEG or other water-soluble organic polymers are described. New water-soluble polymeric reagents are provided. The water-soluble polymeric reagents include hydrazine, hydrazine carboxylate, semicarbazide, thiosemicarbazide, carboxylic acid dihydrazide, carbazide, thiocarbazide and arylhydrazide derivatives as well as oxyamine paraffinic acid, polyethylene glycol, polyethylene glycol, and polyvinyl alcohol. Relevant peptides were also obtained which are derivatized by the present water-soluble polymeric reagents. Kits were also described for modifying polypeptides with the present water-soluble polymeric reagents.
priorityDate 1992-12-09-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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