| abstract |
2- [2- (4-chlorophenyl) -2- (hydroxy or oxo) ethyl] -2,4-dihydro-4- [4- [4- (4-hydroxyphenyl) -1-piperazinyl] phenyl] -5 -methyl-3H-1,2,4-trilazol-3-one of formula (I) wherein X is C = O or CHOH for use as 5- 11poxygenase inhibitors. Pharmaceutical compositions, process for the preparation of the compounds and preparations, and a method for the treatment of leukotrlen-mediated diseases are described. |