| abstract |
Novel pyrimidine derivatives having excellent antitumor activity and having the following general formula (I) or pharmacologically salable salts thereof: (CH:) n-A-Rs-CONH-CH-CO, R! CH 3 CH 2 CO 1 R (I) wherein R 1 is hydroxyl or amino, R 2 is phenylene, pyridinediyl, tenenedyl, furanediyl or thiazole diyl, -C C - is N-CH2-CH2-, N-CH = CH- \ s * "" "or CH-CH2-CH2, A is oxygen, a group of the formula: \ R3: -C- (wherein R3 and R4 are the same or different and each R 4 is hydrogen or halogen or a hydrocarbon group which may be substituted, or R 3 and R 4 may optionally form together an alkylidene group which may be substituted) or a group of the formula: R 70 (wherein R 70 is hydrogen or; -N - a hydrocarbon group), and n is an integer from 1 to 3, provided that the compound wherein R 1 is oxygen and hydrogen is bonded to nitrogen at the 3-position is included in the above definition. A process for the preparation of the derivatives is also disclosed in conjunction with anti-tumor drugs containing the same. |