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filingDate 1990-08-21-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 1990-08-21-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber NO-903681-L
titleOfInvention MONOCLONAL ANTIBODIES AGAINST ACTIVATED RACE PROTEINS WITH AMINO ACID MUTIONS IN POSITION 13 IN THE PROTEIN.
abstract Monoclonal antibodies that react with oncogenic and activated ras-p21 proteins that contain aspartic acid or valine at position 13, and that do not react with normal ras-p21 proteins that contain glycine at position 13. The antibodies are secreted by hybridomas obtained by immunizing mice with synthetic peptides which in amino acid sequence correspond to positions 5-19 in normal ras-p21 proteins, except that they have aspartic acid or valine instead of glycine at position 13, and except - from the addition of cysteine at the amino terminus to the peptide . The antibodies and the immunologically reactive fragments can be used in the diagnosis, staging and classification of malignant and premalignant lesions.
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