| abstract |
A unit dosage form, such as a capsule or the like, for delivering drugs to the body in a circadian manner, which includes one or more populations of propranolol-containing particles (beads, pellets, granules, ether). Each bead population exhibits a pre-designed rapid or sustained release profile with or without a predetermined delay time of 3 to 5 hours. Such a circadian rhythm release cardiovascular drug delivery system is designed to provide a plasma concentration - time profile, which varies according to physiological needs during the day, i.e. mimicking the circadian rhythm and severity manifestation of a cardiovascular disease and pharmacodynamic and pharmacodynamic disease based on in vivo correlations. |