abstract |
The invention relates to quinazoline derivatives of formula I: wherein each of R 1, X 1, R 2, R 3, R 5, n and m has any of the meanings defined in the specification; methods for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an antiproliferative agent for the prevention or treatment of tumors sensitive to inhibition of EGF and erbB receptor tyrosine kinases. |