| abstract |
Device for long-term controlled release of a drug having antiprogestin properties. The device comprises a core comprising the drug, and optionally a membrane that encloses the core. The core and / or membrane is made of a siloxane-based elastomeric material comprising at least one elastomer and optionally a non-crosslinked polymer. The elastomeric material comprises groups of polyalkylene oxide and the polyalkylene oxide groups are present in the elastomer or polymer as alkoxy terminated grafted polysiloxane units or as blocks, or as a mixture of these forms, wherein the graft or blocks are bonded to the polysiloxane units with silicon-carbon bonds. |