| abstract |
The present invention relates to a compound of general formula (I) wherein Het is an optionally substituted 4-, 5-, 6- or 7-membered heterocyclic ring having at least one nitrogen atom; R 1 is hydrogen, hydroxy, C 1 -C 4 alkyl, C 3 -C 4 cycloalkyl, C 2 -C 4 alkenyl or C 2 -C 4 alkynyl; R 2 and R 3 are independently selected from hydrogen, C 1 -C 4 alkyl, C 3 -C 4 cycloalkyl, C 2 -C 4 alkenyl, C 2 -C 4 alkynyl, C 1 -C 4 alkoxy, halogen and cyano, provided that R 2 and R 3 are not both hydrogen; R4 is C1-C4 alkyl, C3-C4 cycloalkyl, C2-C4 alkenyl or C2-C4 alkynyl; Ar is an optionally substituted aromatic ring system selected from pyridinyl; 1-naphthyl; 5,6,7,8-tetrahydro-l-naphthyl; quinolinyl; 2,3-dihydro-l, 4-benzodioxinyl; 1,3-benzodioxolyl; 5,6,7,8-tetrahydroquinolinyl; 5,6,7,8-tetrahydroisoquinolinyl; 5,6,7,8-tetrahydroquinazolin-4-yl; l-benzo [b] thiophen-7-yl; 1-benzo [b] thiophen-4-yl; l-benzo [b] thiophen-3-yl; isoquinolinyl; quinazolinyl; and indan-4-yl; or Ar is substituted phenyl; or an enantiomer thereof or any salt thereof; a pharmaceutical composition containing said compounds or the use of said compounds in therapy. The present invention further relates to processes for the preparation of compounds of formula I and novel intermediates used in their preparation. |