| abstract |
The invention relates to compounds of the general formula (1) wherein R 1 is lower alkyl, lower alkoxy, pyridinyl ,. pyrimidinyl, phenyl, -S-lower alkyl, -S (O) -lower alkyl, -. N (R) - (CH 2) -N (R), -O- (CH 2) -N (R), -N (R) or a cyclic tertiary amine from the group which may contain an additional heteroatom selected from N, O or S, and wherein this group may be attached to the pyrimidine ring through the group -O (CH) -; R is hydrogen, lower alkyl, lower alkoxy, halogen or trifluoromethyl; R / R is independently -hydrogen or lower alkyl; Stir independently halogen, trifluoromethyl or lower alkoxy; R is hydrogen or lower alkyl; R is independently hydrogen or lower alkyl; X is -C (O) N (R) - or -. N (R) C (O) -; Y is -O-, -S-, -SO-, - or -N (R) -; n is 1, 2, 3 or 3; and m is 0, 1 or 2; and pharmaceutically acceptable acid addition salts thereof. They have a good affinity for the NK 1. receptor, they are therefore suitable for the treatment of diseases related to this receptor. |