| abstract |
New methods for treating or reducing the likelihood of acquiring symptoms or illnesses due to menopause in postmenopausal women, in particular osteoporosis, vaginal atrophy and dryness, hypogonadism, reduced libido, skin atrophy, connective tissue disease, urinary incontinence, breast, endometrial, endometrial, are described. - and uterine cancer, fever, loss of muscle mass, insulin resistance, fatigue, loss of energy, aging, physical symptoms of menopause, in various warm blooded animals including humans, involved administration of a sex steroid precursor. The method includes novel routes of administration and dosing of dehydroepiandrosterone (DHEA) to take advantage of the positive, androgenic effects in the vaginal layers of lamina propia and / or layered muscularis, without and undesirably causing systemic, estrogenic effects to avoid the risk of breast cancer. and uterine cancer. Further, pharmaceutical compositions for the administration of one or more active ingredients useful as described above are disclosed. |