| abstract |
The following specific compounds: {7-cyano-2-methyl-1- [4- (morpholine-4-sulfonyl) benzyl] indolizin-3-yl} acetic acid, [1- (3-chloro-4-ethanesulfonylbenzyl) -7- cyano-2-methylindolizin-3-yl] acetic acid, {1- [3-chloro-4- (morpholine-4-sulfonyl) benzyl] -7-cyano-2-methylindolizin-3-yl} acetic acid, [1- ( 3-chloro-4-ethanesulfonylphenylsulfanyl) -7-cyano-2-methylindolizin-3-yl] acetic acid, {1- [3-chloro-4- (morpholine-4-sulfonyl) phenylsulfanyl] -7-cyano-2-methylindolizine -3-yl} acetic acid, [7-cyano-1- (6-fluoroquinolin-2-ylmethyl) -2-methylindolizin-3-yl] acetic acid, are ligands to the CRTH2 receptor and are useful in the treatment of respiratory diseases. |