| abstract |
The present invention relates to sulfonylpyrazoline carboxamidine derivatives as antagonists of 5-HT6 receptors, processes for the preparation of these compounds and novel intermediates useful for their synthesis. The compound also relates to the uses of such compounds and compositions, particularly their use in administering them to patients to achieve a therapeutic effect in Parkinson's disease, Huntington's chorea, schizophrenia, anxiety, depression, manic depression, psychoses, epilepsy, obsessive compulsive disorders, mood disorders, migraines, Alzheimer's disease, age-related cognitive impairment, mild cognitive impairment, sleep disturbances, eating disorders, anorexia, bulimia, overeating disorders, panic attacks, akathisia, attention deficit hyperactivity disorder, attention deficit disorder, attention deficit disorder, attention deficit disorder , disorders associated with spinal trauma or head injury, hydrocephalus, functional bowel disorder, Irritable Bowel Syndrome, obesity and type-2 diabetes. The compounds have the general formula (1): wherein the symbols have the meanings given in the description. |