| abstract |
A contrast agent or pharmaceutically acceptable salt thereof is disclosed, wherein said contrast agent has the formula: IEM- [Lm- (BHEMs-PPBMo) p] q Where m, s, o, p and q are one; Where said IEM is an image enhancing unit comprising a metal-ligand complex of a paramagnetic metal ion selected from the group consisting of Gd (III), Fe (III), Mn (II), Mn (III), Cr (III), Cu ( II), Dy (III), Tb (III), Ho (III), Er (III) and Eu (III), wherein said L is a linker; wherein said BHEM is a phosphodiester unit; and wherein said PPBM is an HSA plasma protein binding moiety comprising at least seven carbon atoms. |