| abstract |
The invention consists of compounds of Formula 1: wherein, R, is independently H or halogen; R 2 is, for example, H or - R 10 -NR 11 R 12, and wherein R 10 is C 1 -C 6 alkyl, and R 11 and R 12 are independently H, C 1 -C 4 alkyl or R 11 and R 12 are chain to form a 5-10 atomic heterocycloalkyl ring and hydrates, solvates, salts and tautomers thereof. The invention further encompasses methods of making compounds of the invention and methods of making compounds useful in the treatment or prevention of cardiac arrhythmia from the compounds of the invention. 47 |