| abstract |
The present invention relates to the compounds of the formula N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein m represents 1, n represents 1, Z represents N or C, especially N; -X1- represents C1-4alkyl, especially methyl; -X2- represents -C1-4 alkyl- or -C1-4alkyl-NR7-, especially propyl, -ethyl-NR7- or -propyl-NR7-; -Y- represents -NR2-C1-6 alkyl-CO-NR4-, -Het1-C1-6alkyl-CO-NR5- or -Het2-CO-NR6- and, wherein -C1-6 alkyl linker in -NR2-C1- 6alkyl-CO-NR4 or -Het1-C1-6alkyl-CO-NR5- is optionally substituted with one or where possible two or more substituents selected from hydroxy, halo and phenyl; R 1 represents hydrogen, chlorine, fluorine or bromine; R 2 represents -C 1-4 alkyl-, especially ethyl or methyl; R7 represents hydrogen; R8 represents hydrogen; R4, R5 and R6 represent hydrogen; Het1 is selected from piperazinyl or piperidinyl, especially -piperazinyl; Het 2 selected from pyrrolidinyl or piperidinyl, especially pyrrolidinyl, wherein said pyrrolidinyl is optionally substituted by hydroxy. |