abstract |
The present invention is directed to novel indolecarboxamide derivatives. Specifically, the invention is directed to compounds of formula I: Formula (I) wherein R1, R2, R3, U and V are defined below, and to pharmaceutically acceptable salts thereof. The compounds of the invention are inhibitors of IKK2 and may be useful in the treatment of disorders associated with adverse IKK2 (also known as IKKP) activity, such as rheumatoid arthritis, asthma and COPD (chronic obstructive pulmonary disease). Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is also further directed to methods for inhibiting IKK2 activity and the treatment of disorders associated therewith, using a compound of the present invention or a pharmaceutical composition comprising a compound of the invention. |