| abstract |
The present invention relates to novel substituted steroid derivatives which are selective inhibitors of 17? of these compounds. In addition, the invention relates to the therapeutic use of the novel substituted steroid derivatives, in particular their use in the treatment or prophylaxis of steroid hormone-dependent diseases or disorders, such as steroid hormone. dependent diseases or disorders requiring the inhibition of 17β-hydroxysteroid hydrogenase type I and / or steroid sulfatase enzymes, and / or requiring a decrease in the concentration of endogenous 17β-estradiol. |