| abstract |
The invention provides certain compounds and salts of Formula I and Formula II:. which invention has antimicrobial activity. The invention also provides novel synthetic intermediates useful for the preparation of compounds of formula I and formula II. The variables AR, R, R, R, R ?, and Rer are defined herein. Certain compounds of Formula I and Formula II described herein are potent and selective inhibitors of bacterial DNA synthesis and bacterial replication. , containing one or more compounds of Formula I or Formula II and one or more carriers, additives or diluents. Such compositions may contain a compound of Formula I or Formula I as the sole active agent or may contain a combination of a compound of Formula I or Formula II and one or more other active agents. The invention also provides methods for treating microbial infections in animals. |