| abstract |
The N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemistry isomeric forms thereof, wherein 1,2, 3 or 4 are included; Z represents O, S, NR 2 SO or SO 2; represents hydrogen, cyano, hydroxy, or C 1-4 alkyl optionally substituted with halo, R 4 represents hydrogen, C 1-4 alkyl or C 1-4 alkyloxy; R 2 represents hydrogen, C 1-4 alkyl, C 1-4 alkyloxy or R 2 combined with R 3 together form a divalent radical selected from the group consisting of -O-CH 2 - (a), -NR 2 -CH 2 - (b), - (CR'R ') ¿> - (c) and -CS} ° = (d) wherein m represents 1 or 2 and R 1, R', R 'and R' 'are each independently selected from hydrogen or C 1-4 alkyl; R 'represents hydrogen, halo, hydroxy, cyano, amino, NR NRR R, C Ciyalkalkyloxy optionally substituted with one or where possible two or three substituents selected from hydroxy and halo or R' represents C with one or where possible two or three substituents selected from hydroxy and halo; R 2 represents hydrogen, halo, cyano, amino, phenyl, hydroxy, C 1-4 alkyloxycarbonyl, hydroxycarbonyl, NR 1 R 4 four substituents selected from hydroxycarbonyl, phenyl, C 1-4 alkyloxy or NR'R '; R' represents hydrogen; R 'and R' 'each represent independently hydrogen, C 1-4 alkyl or C 1-4 alkylcarbonyl-; r "and R" represent each independent hydrogen, C 1-6 alkyl or C 1-4 alkylcarbonyl-; R "and R" each represent independent hydrogen, C 1-6 alkyl or C 1-4 alkylcarbonyl-; R "and R" each independently hydrogen, C 1-4 alkyl or C 1-4 alkylcarbonyl-. |