| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_05a203d85ee01909eaf728dc16f0f6cb |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-07 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C33-46
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C33-40
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P7-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P41-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P41-004 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C33-46
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P41-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P7-22 |
| filingDate |
2007-03-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c489664e849ce44a987997125e7482ec
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_db08e93699f53b558c00a2fb406388d1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9d4ff556fc538be8bdc1b6e10fe7fd0d |
| publicationDate |
2007-05-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
NO-20071298-L |
| titleOfInvention |
Enantioselective biotransformation for preparation of protein tyrosine kinase inhibitor intermediates |
| abstract |
The present invention relates to biocatalytic processes for the preparation of enantiomerically pure stereoisomers of 1- (2,6-dichloro-3-fluorophenyl) ethanol. Described are processes for the preparation of the S-enatiomer which are based on a combination of an asymmetric solution, chemical esterification and chemical hydrolysis with inversion of 1- (2,6-dichloro-3-fluorophenyl) ethyl esters or selective bioreduction and 1 - (2,6-dichloro-3-fluorophenyl) with a biocatalyst such as an enzyme or microorganism. The chiral enantiomer can be used in the synthesis of certain enantiomerically enriched ether-linked 2-amino-pyridine compounds that potently inhibit autophosphorylation of human heptocyte growth factor receptor. |
| priorityDate |
2004-08-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |