| abstract |
A process for the production of cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase IV is provided using a BOC protected amine of structure 3 prepared by subjecting an acid of structure 1 to reductive amination by treating the acid with ammonium formate, nicotinamide -adenine dinucleotide, dithiothreitol and partially purified phenylalanine dehydrogenase / formate dehydrogenase enzyme concentrate (PDH / FDH) and without isolation, treat the resulting amine of structure 2 with di-tert-butyl dicarbonate to form the BOC protected amine. |