| abstract |
The present invention relates to substituted 3,3-diphenyl-1,3-dihydro-indol-2-one compounds, and the use of such compounds for the manufacture of a medicament for the treatment of cancer in a mammal. It is postulated that the compounds inhibit protein synthesis and / or inhibit activation of the mTOR signaling pathway, which is an effective method for reducing cell growth. Examples of such cancers are breast cancer, renal cancer, multiple myeloma, leukemia, glia blastoma, rhabdomyosarcoma, prostate, soft tissue sarcoma, colorectal sarcoma, gastric carcinoma, head and neck squamous cell carcinoma, uterus, cervical, melanoma, lymphoma, and pancreatic cancer. A particular subclass of compounds is represented by Formula (II) wherein at least one of X 1 and X 2 is a heteroatom substituent, for example 6-chloro-3,3-bis- (4hydroxy-phenyl) -7-methyl-1,3- dihydro-indol-2-one. |