| abstract |
The present invention relates to SNS-595 and methods of treating cancer using the same. Figure I shows the plasma concentrations of SNS-595 over time among the different patient groups. SNS is a novel naphthrin cytotoxic compound previously known as AG-7352, see, for example, Tsuzki et al., Tetrahedron Asymmetry 12: 193-1799 (2001) and U.S. Patent No. 5,817,669. The chemical name of SNS-595 is (+) - 1,4-dihydro-7 - [(3S, 4S) -3-methoxy-4- (methylamino) -1-pyrrolidinyl] -4-oxo-1- (2) -tiazolyl) -1,8-naphthyridine-3-carboxylic acid. Some translations are noted and have the structure as shown below. |