| abstract |
This invention provides a compound of formula (I). where. A represents a phenyl group or the like; B represents an aryl group or the like; E represents a 1,4-phenyl group; Rog R independently represents a hydrogen atom or the like. Rog R independently represents a hydrogen atom or the like. Represents independently -COH or similar; Represents an alkyl group having from 1 to 6 carbon atoms or the like; X represents a methylene group or the like. These compounds are useful for the treatment of disease states mediated by prostaglandins, such as pain or the like in mammals. The compounds act as antagonists on the prostaglandin E2 receptor. This invention also provides a pharmaceutical composition comprising the above compound. |