| abstract |
There is disclosed a 5-membered heteroaromatic ring compound represented by formula [I] wherein R 20, R 21, R 22 and R 25 are each H, etc .; E is aryl or a heteroaromatic ring group; R is -COOH, etc .; B is aryl, etc .; R 3 is H, etc .; Y is -C (R13) (R14) -N (R12) -, -C (R13) (R14) -O-, -N (RU) -, -O-, etc .; A is alkylene; and Z is aryl, etc. Further, prodrugs thereof and pharmaceutically acceptable salts thereof are disclosed. The compounds of formula [I] have superior protein tyrosine phosphatase 1B inhibitory activity and are useful as a therapeutic agent for diabetes, diabetic complications, hyperlipidemia, obesity and the like. |