| abstract |
The invention relates to guanidine derivatives of formula (I) wherein: A = a chain of 3-6 C atoms, one of which may be replaced by -N (R ') - or -O-; and R 1 = H or a substituent; wherein the ring skeleton contains only the two double bonds in the thiazole component; pharmaceutically acceptable acid addition salts of basic compounds of formula (I), pharmaceutically acceptable salts of acid group-containing compounds of formula (I) with bases, pharmaceutically acceptable esters of hydroxy or carboxy group-containing compounds of formula (I) and solvates and hydrates thereof; which are partially known and partially novel and exhibit a neuropeptide FF receptor antagonist effect. The above are suitable for the treatment of pain and hyperalgesia, withdrawal symptoms in the case of alcohol, psychotropic and nicotine dependence, for improving or curing these dependencies, for regulation of insulin secretion, food intake, memory functions, blood pressure, electrolyte - and energy control and for the treatment of urinary incontinence. The above can be prepared using generally used methods and processed into medicaments. |