| abstract |
Benzamide inhibitors of the P2X7 receptor of formula I are described, wherein R1 and R2 are as defined in claim 1. R3 is a nitrogen-linked (C1-C10) heterocyclyl of formula (II), wherein R4 and R7 are as defined in claim 1 The compounds are useful in the treatment of IL1-mediated disorders, including inflammatory diseases such as osteoarthritis and rheumatoid arthritis, allergies, asthma, COPD, cancer, reperfusion or ischemia of stroke or cardiac arrest, autoimmune diseases and other disorders. |