| abstract |
A compound of formula (I): (i> (wherein A, B, C and D are independently nitrogen or optionally substituted methine; E is nitrogen, methine or hydroxy substituted methine; n is O or 1; T, U, V and " W is independently nitrogen or nitrogen or substituted methine; X is NN (SO₂R ^ -, -N (COR ^) - or -CO-; Y is -C (R *) (R ') -, -O- or -N (R *), provided that the compound (I) nSr E is nitrogen, n is 0, X is ¿CO- and Y is ¿O- are excluded) are useful as a means of treating various diseases related to! NPY such as cardiovascular diseases such as "angina, acute or congestive heart failure, myocardial infarction, hypertension, neopathy, electrolyte abnormality, vasospasm, atherosclerosis, etc., central nervous system disorders such as bulimia, depression, anxiety, seizures, seizures, , drug withdrawal, circadian Rhythm disorders, schizophrenia, memory impairment, sleep disorders, congenital impairment, etc, metabolic diseases such as obesity, di obesity, hormonal abnormalities, hypercholesterolemia, hyperlipidemia, gout, fatty liver, etc, genital or reproductive disorders such as infertility, premature birth, sexual dysfunction, etc, gastrointestinal disorders, respiratory disorders, inflammation disorders, and glaucoma, and the like. eg atherosclerosis, hypogonadism, hyperandrogenism, polycystic ovarian syndrome, hirsutism, gastrointestinal motility disorder, obesity-related gastro-oesophageal reflux, obesity hypoventilation syndrome (alcohol), sleep apnea, inflammation, systemic inflammation, systemic inflammation , cardiac hypertrophy, left ventricular hypertrophy, hypertriglyceridemia, low HI> L cholesterol, cardiovascular BTB disorders such as coronary heart disease (CHID), cerebrovascular disease, stroke, peripheral vascular disease, sudden death, gallbladder disease, etrial, colon), wheezing, hyperuricemia, impaired fertility, low back pain and increased dementia risk. |