http://rdf.ncbi.nlm.nih.gov/pubchem/patent/NO-20001937-L
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0efa077d881a96aeb1e29b21ef1bbb58 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D275-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-428 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D275-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 |
| filingDate | 2000-04-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_53eea07040e8455bbbf6e6e5ce0a4c24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3a72063d7f1c9bdcf64d4813b6062ddb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ab4b95f0291fec504f6fb70a9ca109c6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e5af29c4e1ea7d25b46a3b06218b379a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f0b9f40ec42275cc5f14f02181959d45 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5c4a3a76bd80e2a65c5ce334bf0fcab0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b74f11fb17beb893fd79018de1174898 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f7b33a3ade3355787509887a0514c877 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_480f7c54fbd8a192ab8827c550eaa62d |
| publicationDate | 2000-04-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | NO-20001937-L |
| titleOfInvention | 2-substituted 1,2-benzisothiazole derivatives and their use as serotonin antagonists (5-HT1A, 5-HT1B and 5-HT1D) |
| abstract | The invention relates to 2-substituted 1,2-benzoisothiazole derivatives of formula I A¿B¿Ar wherein R 1 and R 2 are, independently, (C 1 e) alkyl, R 3, R 4 are independently hydrogen, branched or straight chain ( C 1-6 alkyl, OH, branched or straight chain O- (C 1- 5) alkyl, F, Cl, Br, 1, trifluoromethyl, NR 5 R 6, CO 2 R 7, nitro, cyano, pyrrolyl, a phenylalkyl C may be substituted on the aromatic system by F, Cl, Br, 1, C 1 -C 4 alkyl, C 1 -C 4 alkoxy, trifluoromeryl, hydroxyl, amino, cyano or nitro, R 5 and R 6 are, independently, hydrogen, branched or straight-chain (C1-6) alkyl, COPh, CO2tBu, CO- (C1-6 alkyl or together is a 5- or 6-membered ring which may contain a second nitrogen (e.g. piperazine), R7 is hydrogen and (branched or straight chain C1-12) alkyl, A is branched or straight chain (C1-10) alkyl or straight chain or branched (C2-10) alkyl, comprising at least one group Z selected from O, S, NR7, cyclopropyl, CHOH, a double or a triple bond, B is 1,4-piperidinylene, 1,2,3,6-tetrahydro-1,4-pyridinylene, 1,4-piperazinylene and the corresponding cyclic compounds extended by a methylene group, the bond to A being through a nitrogen atom in B and Ar is phenyl unsubstituted or substituted by branched or straight chain (C 1-6) alkyl, branched or straight chain O- (d 6) alkyl, OH, F, Cl, Br, 1, trifluoromethyl, NR5R6, CO2R7, cyano or phenyl or is tetralinyl, indanyl, condensed aromatic systems such as naphthyl which is unsubstituted or substituted by (C 1-4) alkyl or O (d- 2 heteroatoms selected independently of one another from O and N, and which may also be condensed to other aromatic residues such as quinoline, isoquinoline, phthalazine, indole and quinazoline, which themselves may be substituted with phenyl; and R3 and R4 have the meanings set forth in the specification. The invention also relates to the preparation of the invented derivatives and their use as serotonin antagonists. |
| priorityDate | 1997-10-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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