| abstract |
The present invention encompasses structures of Formula (I) or the pharmaceutically acceptable non-toxic salts thereof, wherein: X is hydrogen, halogen, (u) substituted alkyl, (u) substituted alkoxy or amino; and Y is (u) substituted alkyl, aryl or heteroaryl, which compounds are highly selective agonists, antagonists or inverse agonists for GABAa brain receptors or pro-drugs of agonists, antagonists or inverse agonists for GABAa brain receptors. These compounds are useful for the diagnosis and treatment of anxiety, Down Syndrome, sleep disturbance, cognitive disorders as well as seizures and overdoses with benzodiazepine drugs and for the reinforcement, of wakefulness. |