| abstract |
New, therapeutically effective vinylthio-acetamido-oxacephalosporin derivatives with it. general formula :. wherein u is hydrogen, carboxamido, N-hydroxy-carboxamido, carboxy, azido, aryl, acylamino ,. protected carboxy or N-alkoxycarboxamido ,. or may together with v be -S- or -CHS- ;. v is hydrogen, halogen, cyano or alkylthio ,. or may together with be -S- or -CHS-,. or may together with w be - (CH 2) CO-; w er. hydrogen, carbamoyl, cyano, carboxy, N-alkyl-carbamoyl, alkyl, aryl, protected carboxy or. a heterocyclic group, or may together with. v be - (CH) CO-; x is halogen, trlfluoromethyl ,. alkylthio or arylthio; y is hydrogen, et. light metal or a carboxylic acid protector. group; and z is acyloxy or heterocyclic. thio, each of the above groups u, v, w, x, y and z being optionally substituted by halogen or a carbon-, nitrogen-, oxygen- or sulfur-containing functional group.The new compounds show antibiotic action against gram-positive and gram-negative bacteria The preparation of the compounds is described. |