| abstract |
Bicyclic sulphonamides and their addn. and quat. salts are new: where Y = N, N-CH3 or CH; R1 = H, opt. substd. lower alkyl, formyl, halophenylpropargyl, opt. substd. aralkyl or opt. substd. phenyl; and R2 = -W-N(R3)-CH(R4)-(X)m-Ar(R5)(R6)(R7) (II) or (III); R3 = H, opt. substd. lower alkyl, formyl, halophenylpropargyl, opt. substd. aralkyl or opt. substd. phenyl or R3 + R1 = lower alkylene; R4 = H or lower alkyl; R5 = H, halogen, nitro, lower alkyl, opt. substd. hydroxyl, opt. N-substd. amino, opt. substd. carboxy, polyfluoro-lower alkyl, cyano, hydroxymethyl, methylthio, methylsulphinyl or methylsulphonyl; and R6 = H, halogen or lower alkoxy; or R5 + R6 = lower alkylenedioxy; R7 = H or lower alkoxy; X = vinylene or ethynylene; Ar = phenyl, naphthyl or heterocyclyl gp.; m = 1-3; W = lower alkylene, opt. substd. phenylene or opt. substd. phenylene-lower alkylene; R10 = H, nitro, opt. substd. amino, opt. substd. hydroxyl, lower alkyl or halogen or R10 + R1 = lower alkylene; R11 = H, hydroxyl or lower alkoxy; R12 = R13 = H or R12+R13 = oxo; n = 1-3; A = CR14R15 or NR14; R14 = H, opt. substd. hydroxyl, opt. substd. phenyl, acryl, substd. carbonyl, opt. substd. alkoxycarbonyl, substd. carbamoyl, opt. substd. amino, arylsulphonyl, aralkylsulphonyl, aralkyl or heterocyclyl gp.; and R15 = H or lower alkyl; or R14+R15 = alkylenedioxy or oxo. |