http://rdf.ncbi.nlm.nih.gov/pubchem/patent/NL-9401404-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e7b4cfdb9bbecbd66983b86883d586f6 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-501 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-2809 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-1077 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-107 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-28 |
| filingDate | 1994-08-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b3ef2ca73d30c65129ea63fbe72379d0 |
| publicationDate | 1996-04-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | NL-9401404-A |
| titleOfInvention | Gradual chemical modification of biologically active peptides and proteins. |
| abstract | The present invention relates to the gradual modification of biologically active peptides and proteins. By carrying out the reaction in a gradually increasing manner, a desired biological change in activity is applied with minimal modification. The desired biological change in activity is preferably one or more of the following changes: enhanced activity, reduced antigenicity, an antagonistic activity, a cell-inhibiting activity. The novel products found with the abovementioned techniques and the use of those products fall within the scope of the invention. Optimum control of the modifications can be achieved by means of a technique of locating modifications in a peptide or protein with the aid of a protease treatment and mass spectrometry. Apart from simple dialysis, no purification at all is required, thus allowing a desired biological change in activity to be effected with small amounts of the native peptide or protein. Moreover, the method is simple and rapid, and allows structural verification of the modified protein or peptide in practice. Consequently, it is possible for a complete structure-function relationship study to be carried out in conjunction with biological assays. It was also found that the modification of residues involved directly or indirectly in catalytic activity, preferably of histidine residues, of a signal peptide or protein enables the introduction of a novel, preferably antagonistic activity and/or cell-inhibiting activity. Here, the modification is preferably chemical and preferably gradual. Moreover, the reaction is preferably carried out under conditions at which metal ions are abstracted from the peptide or protein. |
| priorityDate | 1994-08-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 142.