| abstract |
New opt. modified (e.g. glycosylated) peptides (I) comprise at least 7 amino acids and have a N-terminal sequence of formula A1-A2-A3-A4-A5 (Ia). A1 = Pro, Ala, Met, Tyr, Val, Ile, Leu, Phe, Cys or Trp; A2 = Gly, Asp, Glu, His, Lys or Arg; A3 and A4 = any amino acids; A5 = Asp, Glu, His, Lys or Arg. Also claimed are protein constructs (II) comprising at least one fragment contg. a B cell epitope and at least one fragment of type (I), where the N terminus of (I) is adjacent to two hydrophobic amino acids, each selected from Pro, Ala, Met, Tyr, Val, Ile, Leu, Phe, Cys or Trp. Pref. (I) have A2 and A5 = His, Lys or Arg. They comprise 7-40 amino acids and have two hydrophobic amino acids at the C terminus. |