http://rdf.ncbi.nlm.nih.gov/pubchem/patent/NL-8601026-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_75a4811e7eae15e0f1e32cc6a222ce30 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-20 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-20 |
| filingDate | 1986-04-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1986-08-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | NL-8601026-A |
| titleOfInvention | Novel 7-alpha-methoxycyphalospores and process for their preparation |
| abstract | Cephalosporins of formula (I) and their salts are new. In (I) R1 is H or protecting gp. R2 is organic gp. bonded via an O or S atom. esp. acetoxy or a substd. 5-(1,2,3,4-tetrazolyl)thio or 2-(1,2,3,4(sic)-thiadiazolyl)thio. R3 is lower alkyl. n is 0-2.A is H or opt. substd. alkyl. B is alkyl, cycloalkyl, cycloalkenyl, cycloalkadienyl or heterocyclyl, all opt. substd. They are prepd. e.g. by reacting a 7-(alpha-aminoacetylamino)cephem with a reactive deriv. of 4-A-2,3-dioxo-piperazine-1-carboxylic acid. (I) are esp. effective against Pseudomonas aeruginosa, Klebsiella pneumoniae and Proteus. They are useful in human or veterinary medicine. A typical cpd. 7 beta- D(-)-alpha-(4-ethyl-2,3-dioxo-1,piperazinecarboxamido)-alph- a-(2-thienyl)-acetamido -7 alpha-methoxy-3 5-(1-methyl,1,2,3,4-tetrazoyl)thiomethyl -DELTA3-- cephem-4-carboxylic acid (Ia) has intravenous LD50 in mice =5g/kg and has ID50 against beta-lactamase from E. coli GN-5482 of 0.82 mu g/ml. |
| priorityDate | 1977-07-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 157.