http://rdf.ncbi.nlm.nih.gov/pubchem/patent/NL-8201327-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d629f98a51b15993f56f9e04fdea237f |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H15-236 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H15-236 |
| filingDate | 1982-03-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1982-08-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | NL-8201327-A |
| titleOfInvention | METHOD FOR PREPARING A PHARMACEUTICAL PREPARATION WITH ANACTIVITY AGAINST BACTERIA, AND METHOD FOR PREPARING AN SUITABLE ACTIVE COMPOUND. |
| abstract | derivs. (I) of gentamicin A, B1, C1, C1a, C2a, C2b, sisomicin; verdamicin; tobramycin; antibiotics G-418, 66-40b, 66-4OD, J1-20A, J1-20B, G-52; mutamicins 1,2,4,5 or 6, substd. on the 1-N atom by CH2X or COZ (where X = H, alkyl, alkenyl, cycloalkyl, cycloalkylalkyl, hydroxyalkyl, aminoalkyl, N-alkyl aminoalkyl, aminohydroxyalkyl, N-alkyl aminohydroxyalkyl, phenyl, benzyl or tolyl; aliphatic gps. have is not >7C and hydroxy and amino when both present are on separate C atoms; Z = X, provided that COZ is other than 5-3-amino-2-hydroxypropionyl, S-4-amino-2-hydroxybutyryl or (only for tobramycin) S-5-amino-2-hydroxyvaleryl) and their acid addn. salts are broad-spectrum antibacterials active against some strains resistant to the parent 1-amino cpds.; some are also antiprotozoals, antiamoebics and anthelmintics. They are be used therapeutically in human or veterinary medicine (e.g. 1-N-ethylsisomicin and 1-N-ethylverdamicin are useful for controlling mastitis, and Salmonella infections in cats) or as surface disinfectants. (I; COZ) are intermediates for (I; CH2X). |
| priorityDate | 1973-08-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 79.