http://rdf.ncbi.nlm.nih.gov/pubchem/patent/NL-7701227-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_df4e72183c5ee38a234212562dca6570 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D513-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D217-16 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D513-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D217-16 |
| filingDate | 1977-02-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1978-08-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | NL-7701227-A |
| titleOfInvention | NEW THIAZOLO (3,4-B) ISOCHINOLINE, ITS PREPARATION AND PREPARATIONS CONTAINING THE NEW DERICAS. |
| abstract | Thiazolo-isoquinolines of formula (I), in (R) or (S) forms or their mixts. and their acid addition salts are new. In the formula, X1=H, halo, CH3O or CN. X2=H, halo or CH3O; or X1 + X2 = methylenedioxy. Y1 and Y2 = H, halo, 1-4C alkyl, alkoxy or alkylthio, OH diacetylamino or NH2. They are prepd. e.g. by acid cyclisation of 2-(pyridylaminothiocarbonyl). 3-hydroxymethyl-tetrahydroisoquinoline. (I) are anti-ulcer agents e.g. they antagonise the histamine-induced gastric acid secretion at 10-50 mg/kg orally and some are effective against experimentally-induced gastric ulcers at 20-100 mg/kg. Toxicity is >=100 mg/kg orally and most show no signs of toxicity at 900 mg/kg orally in mice. A typical cpd. is (5)-3-(2-pyridylimino)-1,5,10,10a-tetrahydrothiazolo 3,4,b isoquinoline. |
| priorityDate | 1977-02-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 19.