http://rdf.ncbi.nlm.nih.gov/pubchem/patent/NL-6908207-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D231-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D231-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D231-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D231-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D231-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D231-38 |
| filingDate | 1969-05-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1970-12-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | NL-6908207-A |
| titleOfInvention | Pyrazolodiazepinones sedatives |
| abstract | Cpds. of formula (I) and their salts: where R1 = Me or Et, R2 = C1-3 alkyl or allyl, R3 = H or Me, X1 = H, Cl, or CF3. (I) have CNS sedative activity, as shown by their anticonvulsant effect in the anti-pentamethylene-tetrazole test (pharmacological data are given in the specification). (II; R1 = R2 = Me, R3 = H, X1 = H) (9 g.), EtOOCCH2NH2.HCl (18 g.), piperidine (2 ml.), and pyridine (100 ml.) are stirred 30 hrs. at reflux, then evapd. to dryness under reduced pressure. The residue is partitioned between CH2Cl2 (250 ml.) and H2O (100 ml.). The CH2Cl2 phase is separated, treated with active charcoal and Na2SO4, filtered and evapd. under reduced pressure (I; R1 = R2 = Me, R3 = X1 = H), m.p. 267 - 70 deg. (from EtOH). 2.5 g. of the base are dissolved in 15 ml. of ethanolic HCl. |
| priorityDate | 1969-05-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 26.