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publicationDate 2019-11-12-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber NL-2020862-B1
titleOfInvention Probing mechanical properties of biological matter
abstract A method for probing mechanical properties of cellular bodies is described wherein the method includes: providing a 5 plurality of particles in a fluid medium contained in a holding space of a sample holder, each of the plurality of particles being attached to a cellular body and each cellular body being positioned on a surface of the holding space; generating a resonant bulk acoustic wave in the holding space, the resonant 10 bulk acoustic wave exerting an acoustic force on each of the plurality of particles in a direction away from the surface of the holding space or in a direction towards the surface of the holding space, each of the plurality of particles having an acoustic contrast factor and a size, the acoustic contrast 15 factor and the size being selected such that the force exerted on a particle is larger than the force exerted on the cellular body to which the particle is attached; and, for at least part of the particles attached to the cellular bodies, measuring a displacement of a particle in response to the exertion of the 20 force on the particle, the measured displacement being associated with at least one mechanical property of the cellular body attached to the particle. Fig. ZB
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