http://rdf.ncbi.nlm.nih.gov/pubchem/patent/NL-1018360-C1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1bde28565d28f037e78bf4a67776ee24 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-87 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-24 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B61-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-87 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/H01L21-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-24 |
| filingDate | 2001-06-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2001-10-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bcdefeccbb19703e609c591b5f35f7d9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fab9bd5f2956a73ab96a12ae41662b6c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c75f07838a8a23c74523afb6436a2ab3 |
| publicationDate | 2001-10-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | NL-1018360-C1 |
| titleOfInvention | Process for the preparation of pure Citalopram. |
| abstract | Preparation of citalopram involves removal of the desmethyl-citalopram impurity by reaction with an amide or an amide-like group forming agent; removing the amides, and further purifying the crude product to isolate the base citalopram. Preparation of citalopram (I) by subjecting a compound of formula (II) to a cyanide exchange reaction with a cyanide source involves: optionally subjecting the resultant crude (I) to initial purification; subsequently treating with an amide or an amide-like group forming agent (a) R-CO-X; Hal-C(Y')-W'-R or R'-SO2-Hal; subjecting the reaction mixture to an acid/base wash and/or crystallization and recrystallization to remove the amides formed from the crude mixture; optionally purifying the resulting product of (I), working up and isolating (I) as a base or a salt. Z = I, Br, Cl, CF3-(CF2)nSO2-O-; n = 0 - 8; X = halogen or O-CO-R'; Y' = O or S; W' = O, N or S; and R, R', R and R' = H, alkyl or optionally substituted aryl or aralkyl. |
| priorityDate | 2000-12-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 56.