| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f52c68e4149a6c462b850d4e7cc2b2f9 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2121-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-0478
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-1075
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-0482
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-81
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-1093 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-81
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K51-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K51-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate |
2018-12-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f0e2846a3e2ebb9deff876622137fb49
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7f3a6a0f6e923dde5955ecafd4671828
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ff8f5e70436fd3fc080036fb515ca0c1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_40274d8282d53d95f3a96f636837685b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e52a3b67e5ecf3e64fb1af4f3ffe3469 |
| publicationDate |
2019-04-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
NI-201800136-A |
| titleOfInvention |
RADIO-PHARMACEUTICAL COMPLEXES |
| abstract |
The invention provides a method for the formation of a thorium complex that targets tissue, said method comprising; a) forming an octadentate chelator comprising four hydroxypyridinone (HOPO) moieties, substituted in the N position with a methyl group, and a coupling moiety ending in a carboxylic acid group; b) coupling said octadentate chelator to at least one tissue-targeting moiety that targets prolyl endopeptidase FAP; and c) contacting said tissue-targeting chelating agent with an aqueous solution comprising an ion of at least one alpha-emitting thorium isotope. A method is provided for the treatment of a neoplastic or hyperplastic disease comprising the administration of a thorium complex that targets such tissue, as well as the corresponding complex and pharmaceutical formulations. |
| priorityDate |
2016-06-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |